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How Effective Are Nootropics and “Smart” Drugs? And one study, published in the journal Biological Psychology, found that L theanine reduces psychological and physiological stress responses—which is why it’s often taken with caffeine. In fact, in a 2014 systematic review of 11 different studies, published in the journal Nutrition Review , researchers found that use of caffeine in ... Nootropics Review Best Smart Drug Brain Supplement Guide Though the popularity of nootropics have increased tenfold in the past few years, due in large part to massive media hits like Limitless, public knowledge of the reality of nootropics remains astonishingly low.Thus, it is fitting that this guide begins with a basic introduction into what constitutes a nootropic.. 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